ODCs

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5 OMIM references -
5 associated genes
6 signs/symptoms

COMMON GENES: 1
PROTEIN INTERACTIONS: 1
COMMON SIGNS: 5

1 OMIM reference -
1 associated gene
12 signs/symptoms

Hereditary persistence of fetal hemoglobin - beta-thalassemia

Beta-thalassemia intermedia


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	HBG2	(0.52)	HBB

Citations in the biomedical literature:

Hereditary persistence of fetal hemoglobin - beta-thalassemia		Beta-thalassemia intermedia
	Synonym(s): - HPFH - beta-thalassemia		Synonym(s): (no synonyms)

	Classification (Orphanet): - Rare genetic disease - Rare hematologic disease		Classification (Orphanet): - Rare genetic disease - Rare hematologic disease - Rare renal disease

	Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -		Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -

	Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: no data available Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: - Type of inheritance: autosomal recessive

	External references: 5 OMIM references - No MeSH references		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Anaemia - Anomalies of bones / skeletal anomalies - Hemoglobinosis / hemoglobinopathy - Hepatomegaly / liver enlargement (excluding storage disease) - Splenomegaly

Hereditary persistence of fetal hemoglobin - beta-thalassemia		Beta-thalassemia intermedia
	Very frequent - Pallor		Very frequent - Microcytic anemia Frequent - Biliary / gallbladder stones / lithiasis / cholecystitis - Hyperferritinemia / iron overload Occasional - Chronic skin infection / ulcerations / ulcers / cancrum - Hepatic / liver neoplasm / tumor / carcinoma / cancer - Pulmonary hypertension - Venous thrombosis / phlebitis / thrombophlebitis